Surgical resection is an important avenue for cancer treatment, which, in most cases, can effectively alleviate the patient symptoms. However, accumulating evidence has documented that surgical resection potentially enhances metastatic seeding of tumor cells. In this review, we revisit the literature on surgical stress, and outline the mechanisms by which surgical stress, including ischemia/reperfusion injury, activation of sympathetic nervous system, inflammation, systemically hypercoagulable state, immune suppression and effects of anesthetic agents, promotes tumor metastasis. We also propose preventive strategies or resolution of tumor metastasis caused by surgical stress.
Cancers, Free Full-Text
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Pathology of circulating tumor cells and the available capture
Frontiers Perioperative Inflammatory Response and Cancer
Pharmaceuticals, Free Full-Text
Thorny ground, rocky soil: Tissue-specific mechanisms of tumor
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Glycolysis and oxidative phosphorylation in dormant cancer cells
Repurposing antidepressant sertraline as a pharmacological drug to
A case of disseminated carcinomatosis of the bone marrow from
Surgical stress response and promotion of metastasis in colorectal
